1573 JAK inhibition may prevent drug hypersensitivity reactions
نویسندگان
چکیده
Drug hypersensitivity reactions (DHR) have potential for significant morbidity and mortality, without clear treatment severe reactions. Standard of care is to immediately stop culprit drug(s) never rechallenge. However, the drug and/or whether patient would develop a form DHR unknown. Even if reaction severe, may no alternative their underlying disease. Analysis bulk transcriptional profiling skin specimens suggested activation JAK/STAT pathways in mild (morbilliform eruption) (Stevens-Johnson Syndrome/toxic epidermal necrolysis Reaction with Eosinophilia Systemic Symptoms) DHR, pattern consistent both IFNg IL2Rgc signaling. Immunohistochemical staining activated forms protein confirmed increased expression JAK1, 2 3, STAT1 all three DHR. Two cancer patients developed concerning risk progression disease attributed anti-cancer therapy. Cancer was stopped but neither had an available. Both were successfully prophylaxed non-selective JAK inhibitor, ruxolitinib, prior reinitiating suspected drug. In cases, received therapy reacting. One subsequently completed chemotherapy, underwent surgical tumor resection evidence over one year later. The other tapered off ruxolitinib after 5 months while remaining on targeted follow up to-date. Further research necessary expand reproduce these findings, data support that pharmacologically inhibiting signaling prevent
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ژورنال
عنوان ژورنال: Journal of Investigative Dermatology
سال: 2023
ISSN: ['1523-1747', '0022-202X']
DOI: https://doi.org/10.1016/j.jid.2023.03.1591